(Q22676679)

http://www.ebi.ac.uk/interpro/protein/P22303

Alpha/Beta hydrolase fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22303

membrane protein

1 reference

inferred from GOA cell component → membrane

Carboxylesterase type B

1 reference

Acetylcholinesterase, tetramerisation domain, protein family

1 reference

Carboxylesterase type B, active site, protein family

1 reference

Carboxylesterase type B, conserved site, protein family

1 reference

protein homodimerization activity

image

PBB Protein ACHE image.jpg
500 × 500; 62 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

collagen binding

1 reference

8 April 2019

Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

acetylcholine binding

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

serine hydrolase activity

1 reference

8 April 2019

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

carboxylic ester hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

1 reference

27 March 2018

amyloid-beta binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

protein self-association

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

protein binding

3 references

8 April 2019

Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

ACHE

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

5 references

27 March 2018

27 March 2018

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

27 March 2018

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

27 March 2018

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

acetylcholinesterase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

5 references

1 January 2018

1 January 2018

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

1 January 2018

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

acetylcholinesterase activity

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

cell component

Golgi apparatus

1 reference

8 April 2019

Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

plasma membrane

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

extracellular region

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

8 April 2019

8 April 2019

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

perinuclear region of cytoplasm

1 reference

8 April 2019

Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

anchored component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

synaptic cleft

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

extracellular space

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22303&geneProductId=UniProtKB:P22303

neuromuscular junction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

biological process

muscle organ development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

neurotransmitter biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

negative regulation of synaptic transmission, cholinergic

IC

1 reference

8 April 2019

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

amyloid precursor protein metabolic process

IC

1 reference

8 April 2019

Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

protein tetramerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

neurotransmitter catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

DNA replication

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

retina development in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

response to wounding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

positive regulation of protein secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

osteoblast development

IEP

1 reference

8 April 2019

Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

IEP

synapse assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

phosphatidylcholine biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

1 reference

8 April 2019

regulation of receptor recycling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

acetylcholine catabolic process in synaptic cleft

1 reference

8 April 2019

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22303

physically interacts with

1 reference

6599

17 August 2016

1 reference

6693

17 August 2016

1 reference

8993

17 August 2016

1 reference

6598

17 August 2016

1 reference

7597

17 August 2016

1 reference

8994

17 August 2016

1 reference

6602

17 August 2016

1 reference

6687

English

17 August 2016

pyridostigmine bromide

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL812

edrophonium chloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1128

echothiophate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201341

trans pralidoxime chloride

activation

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL748

ambenonium chloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200541

donepezil hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1678

EC enzyme number

3.1.1.7

1 reference

23 July 2026

1 reference

imported from Wikimedia project

English Wikipedia

Wikimedia import URL

https://en.wikipedia.org/w/index.php?title=Acetylcholinesterase&oldid=950454011

ACHE

0 references

topic's main category

Category:Anticholinesterases

0 references

Identifiers

J9U entity ID

987007532196405171

subject named as (monolingual text)

Acetylcholinesterase (English)

אצטיל-כולין אסטרז (Hebrew)

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

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1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID (discontinued)

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

archive URL

https://web.archive.org/web/20220125070108/https://docs.openalex.org/download-snapshot/snapshot-data-format

25 January 2022

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

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1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

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1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016