Nelonemdaz
(преусмерено са Safaprodil)
 | |
| Pravni status | |
|---|---|
| Pravni status |
|
| Identifikatori | |
| CAS broj | 640290-67-1 |
| PubChem | CID 9951955 |
| UNII | TP6PKI8CQP |
Nelonemdaz je eksperimentalni lek koji deluje kao reduktor slobodnih radikala i selektivni antagonist NMDA receptora 2b. Pretpostavlja se da ima neuroprotektivne efekte kod ljudi koji su nedavno doživeli moždani udar.[1][2][3][4]
Reference
[уреди | уреди извор]- ^ Xu, Xiumei; Chen, Mingyu; Zhu, Dongya (13. 10. 2023). „Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical”. Stroke and Vascular Neurology: svn—2023—002671. doi:10.1136/svn-2023-002671
.
- ^ Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Kwon, Sun U (фебруар 2023). „Abstract TP15: Rationale And Ongoing Status In A Phase 3 Trial Of Nelonemdaz, A Novel Neuroprotection Drug, For Patients With Acute Ischemic Stroke And Reperfusion”. Stroke. 54 (Suppl_1). doi:10.1161/str.54.suppl_1.TP15.
- ^ Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W.; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Shin, Dong-Ick; Kwon, Sun U. (31. 1. 2023). „The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy”. Journal of Stroke. 25 (1): 160—168. doi:10.5853/jos.2022.02453 .
- ^ Hong, Ji Man; Lee, Jin Soo; Lee, Yeong-Bae; Shin, Dong Hoon; Shin, Dong-Ick; Hwang, Yang-Ha; Ahn, Seong Hwan; Kim, Jae Guk; Sohn, Sung-Il; Kwon, Sun U.; Lee, Ji Sung; Gwag, Byoung Joo; Chamorro, Ángel; Choi, Dennis W.; Chammorro, Ángel; Kim, Eung Yeop; Choi, Jin Wook; Yeo, Min-Ju; Kwak, Jaehyuk; Lee, Sung Eun; Hong, Jeong-Ho; Lee, Sangkil; Lee, Yoon-Joo; Lee, Min-Joo (новембар 2022). „Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial”. Stroke. 53 (11): 3250—3259. doi:10.1161/STROKEAHA.122.039649 .
