Pozaniklin

Pozaniklin
Identifikatori
CAS broj	161417-03-4
ATC kod	None
PubChem	CID 178052
UNII	CL2002R563

Pozaniklin (ABT-089) je lek koji je razvilo preduzeće Abbott. On je parcijalni agonist neuronskih nikotinskih acetilholinskih receptora. Pozaniklin je selektivan za podtove α4β2 i α6β2.^[1]^[2] Ovaj ligand ima nootropna i neuroprotektivna svojstva.^[3]^[4]^[5] Životinjske studije sugerišu da on može da bude koristan u lečenju ADHD.^[6]

Reference

^ Marks MJ, Wageman CR, Grady SR, Gopalakrishnan M, Briggs CA (2009). „Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain”. Biochemical Pharmacology. 78 (7): 795—802. PMC 2772152 . PMID 19481067. doi:10.1016/j.bcp.2009.05.022.
^ Anderson DJ, Malysz J, Grønlien JH, El Kouhen R, Håkerud M, Wetterstrand C, Briggs CA, Gopalakrishnan M (2009). „Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination”. Biochemical Pharmacology. 78 (7): 844—51. PMID 19555668. doi:10.1016/j.bcp.2009.06.024.
^ Lin, N. H.; Gunn, D. E.; Ryther, K. B.; Garvey, D. S.; Donnelly-Roberts, D. L.; Decker, M. W.; Brioni, J. D.; Buckley, M. J.; Rodrigues, A. D.; Marsh, K. G.; Anderson, D. J.; Buccafusco, J. J.; Prendergast, M. A.; Sullivan, J. P.; Williams, M.; Arneric, S. P.; Holladay, M. W. (1997 Jan 31). „Structure−Activity Studies on 2-Methyl-3-(2( S )-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties”. Journal of Medicinal Chemistry. 40 (3): 385—390. PMID 9022806. doi:10.1021/jm960233u. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Sullivan, J. P.; Donnelly-Roberts, D.; Briggs, C. A.; Anderson, D. J.; Gopalakrishnan, M.; Xue, I. C.; Piattoni-Kaplan, M.; Molinari, E.; Campbell, J. E.; McKenna, D. G.; Gunn, D. E.; Lin, N. H.; Ryther, K. B.; He, Y.; Holladay, M. W.; Wonnacott, S.; Williams, M.; Arneric, S. P. (1997 Oct). „ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties”. The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235—246. PMID 9336329. doi:10.1016/S0022-3565(24)37014-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Decker, M. W.; Bannon, A. W.; Curzon, P.; Gunther, K. L.; Brioni, J. D.; Holladay, M. W.; Lin, N. H.; Li, Y.; Daanen, J. F.; Buccafusco, J. J.; Prendergast, M. A.; Jackson, W. J.; Arneric, S. P. (1997 Oct). „ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A Novel Cholinergic Channel Modulator with Effects on Cognitive Performance in Rats and Monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247—258. PMID 9336330. doi:10.1016/S0022-3565(24)37015-6. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Prendergast, M. A.; Jackson, W. J.; Terry Jr, A. V.; Decker, M. W.; Arneric, S. P.; Buccafusco, J. J. (1998 Mar). „Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys”. Psychopharmacology. 136 (1): 50—58. PMID 9537682. doi:10.1007/s002130050538. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[pmid19481067-1] Marks MJ, Wageman CR, Grady SR, Gopalakrishnan M, Briggs CA (2009). „Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain”. Biochemical Pharmacology. 78 (7): 795—802. PMC 2772152 . PMID 19481067. doi:10.1016/j.bcp.2009.05.022.

[pmid19555668-2] Anderson DJ, Malysz J, Grønlien JH, El Kouhen R, Håkerud M, Wetterstrand C, Briggs CA, Gopalakrishnan M (2009). „Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination”. Biochemical Pharmacology. 78 (7): 844—51. PMID 19555668. doi:10.1016/j.bcp.2009.06.024.

[3] Lin, N. H.; Gunn, D. E.; Ryther, K. B.; Garvey, D. S.; Donnelly-Roberts, D. L.; Decker, M. W.; Brioni, J. D.; Buckley, M. J.; Rodrigues, A. D.; Marsh, K. G.; Anderson, D. J.; Buccafusco, J. J.; Prendergast, M. A.; Sullivan, J. P.; Williams, M.; Arneric, S. P.; Holladay, M. W. (1997 Jan 31). „Structure−Activity Studies on 2-Methyl-3-(2( S )-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties”. Journal of Medicinal Chemistry. 40 (3): 385—390. PMID 9022806. doi:10.1021/jm960233u. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Sullivan, J. P.; Donnelly-Roberts, D.; Briggs, C. A.; Anderson, D. J.; Gopalakrishnan, M.; Xue, I. C.; Piattoni-Kaplan, M.; Molinari, E.; Campbell, J. E.; McKenna, D. G.; Gunn, D. E.; Lin, N. H.; Ryther, K. B.; He, Y.; Holladay, M. W.; Wonnacott, S.; Williams, M.; Arneric, S. P. (1997 Oct). „ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties”. The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235—246. PMID 9336329. doi:10.1016/S0022-3565(24)37014-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Decker, M. W.; Bannon, A. W.; Curzon, P.; Gunther, K. L.; Brioni, J. D.; Holladay, M. W.; Lin, N. H.; Li, Y.; Daanen, J. F.; Buccafusco, J. J.; Prendergast, M. A.; Jackson, W. J.; Arneric, S. P. (1997 Oct). „ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A Novel Cholinergic Channel Modulator with Effects on Cognitive Performance in Rats and Monkeys”. The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247—258. PMID 9336330. doi:10.1016/S0022-3565(24)37015-6. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[6] Prendergast, M. A.; Jackson, W. J.; Terry Jr, A. V.; Decker, M. W.; Arneric, S. P.; Buccafusco, J. J. (1998 Mar). „Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys”. Psychopharmacology. 136 (1): 50—58. PMID 9537682. doi:10.1007/s002130050538. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

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