Midazolam

Midazolam
Klinički podaci
Prodajno ime	Dormicum, Versed
Drugs.com	Monografija
Način primene	Parenteralno, oralno
Identifikatori
CAS broj	59467-70-8
ATC kod	N05CD08 (WHO)
PubChem	CID 4192
IUPHAR/BPS	3342
DrugBank	DB00683
ChemSpider	4047
KEGG	C07524
ChEMBL	CHEMBL655

Midazolam je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 325,767 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	0
Broj rotacionih veza	1
Particioni koeficijent^[9] (ALogP)	4,1
Rastvorljivost^[10] (logS, log(mol/L))	-6,4
Polarna površina^[11] (PSA, Å²)	30,2

Reference

^ Skerritt, J. H.; Johnston, G. A. (мај 1983). „Enhancement of GABA binding by benzodiazepines and related anxiolytics”. Eur J Pharmacol. 89 (3–4): 193—8. PMID 6135616. doi:10.1016/0014-2999(83)90494-6.
^ Isojarvi, J. I.; Tokola RA. (децембар 1998). „Benzodiazepines in the treatment of epilepsy in people with intellectual disability.”. J Intellect Disabil Res.. 42 (Suppl 1): 80—92. PMID 10030438. . .
^ Garratt, J. C.; Gent, J. P.; Feely, M.; Haigh, J. R. (јануар 1988). „Can benzodiazepines be classified by characterising their anticonvulsant tolerance-inducing potential?”. Eur J Pharmacol. 145 (1): 75—80. PMID 2894998. doi:10.1016/0014-2999(88)90351-2.
^ Tokunaga, S.; Takeda, Y.; Shinomiya, K.; Hirase, M.; Kamei, C. (фебруар 2007). „Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats”. J Pharmacol Sci.. 103 (2): 201—6. PMID 17287588. doi:10.1254/jphs.fp0061173.
^ Vermeeren, A. (2004). „Residual effects of hypnotics: Epidemiology and clinical implications”. CNS Drugs.. 18 (5): 297—328. PMID 15089115. doi:10.2165/00023210-200418050-00003.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Lee Y, Wang JJ, Yang YL, Chen A, Lai HY. (2007). „Midazolam vs ondansetron for preventing postoperative nausea and vomiting: A randomised controlled trial.”. Anaesthesia. 62 (1): 18—22. PMID 17156222. doi:10.1111/j.1365-2044.2006.04895.x. .
^ . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Midazolam Архивирано на веб-сајту Wayback Machine (14. април 2014)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Skerritt, J. H.; Johnston, G. A. (мај 1983). „Enhancement of GABA binding by benzodiazepines and related anxiolytics”. Eur J Pharmacol. 89 (3–4): 193—8. PMID 6135616. doi:10.1016/0014-2999(83)90494-6.

[2] Isojarvi, J. I.; Tokola RA. (децембар 1998). „Benzodiazepines in the treatment of epilepsy in people with intellectual disability.”. J Intellect Disabil Res.. 42 (Suppl 1): 80—92. PMID 10030438. . .

[3] Garratt, J. C.; Gent, J. P.; Feely, M.; Haigh, J. R. (јануар 1988). „Can benzodiazepines be classified by characterising their anticonvulsant tolerance-inducing potential?”. Eur J Pharmacol. 145 (1): 75—80. PMID 2894998. doi:10.1016/0014-2999(88)90351-2.

[4] Tokunaga, S.; Takeda, Y.; Shinomiya, K.; Hirase, M.; Kamei, C. (фебруар 2007). „Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats”. J Pharmacol Sci.. 103 (2): 201—6. PMID 17287588. doi:10.1254/jphs.fp0061173.

[5] Vermeeren, A. (2004). „Residual effects of hypnotics: Epidemiology and clinical implications”. CNS Drugs.. 18 (5): 297—328. PMID 15089115. doi:10.2165/00023210-200418050-00003.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Lee Y, Wang JJ, Yang YL, Chen A, Lai HY. (2007). „Midazolam vs ondansetron for preventing postoperative nausea and vomiting: A randomised controlled trial.”. Anaesthesia. 62 (1): 18—22. PMID 17156222. doi:10.1111/j.1365-2044.2006.04895.x. .

[9] . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)

[10] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[11] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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