Klonazepam

Klonazepam
Klinički podaci
Prodajno ime	Antelepsin, Antilepsin, Cloazepam, Clonopin
Drugs.com	Monografija
Način primene	Oralno
Identifikatori
CAS broj	1622-61-3
ATC kod	N03AE01 (WHO)
PubChem	CID 2802
DrugBank	DB01068
ChemSpider	2700
ChEBI	CHEBI:3756
ChEMBL	CHEMBL452

Klonazepam (Rivotril) je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 315,711 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

U prodaji je najčešće pod imenima Rivotril, ili ređe Klonopin.

Popularizacija zloupotrebe ovog leka je postala šira u periodu 2000ih, i dosta mladih ga rekreativno konzumira, zbog sedativno- anksiolitičkog dejstva koje poseduje, kao i osećaja euforije i "opuštenosti" koju izaziva.

Kao i svaki benzodiazepam, može izazvati veliki oblik zavisnosti.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	1
Broj rotacionih veza	2
Particioni koeficijent^[8] (ALogP)	2,9
Rastvorljivost^[9] (logS, log(mol/L))	-5,2
Polarna površina^[10] (PSA, Å²)	87,3

Reference

^ Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyken P, Sato S: Serum clonazepam concentrations in children with absence seizures. Neurology. Dreifuss, F. E.; Penry, J. K.; Rose, S. W.; Kupferberg, H. J.; Dyken, P.; Sato, S. (1975 Mar). „Serum clonazepam concentrations in children with absence seizures”. Neurology. 25 (3): 255—8. PMID 1089913. doi:10.1212/wnl.25.3.255. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Robertson, M. D.; Drummer, O. H. (1995 May). „Postmortem drug metabolism by bacteria”. J Forensic Sci. 40 (3): 382—6. PMID 7782744. doi:10.1520/JFS13791J. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Rosen GM, Turner MJ 3rd: Synthesis of spin traps specific for hydroxyl radical. Rosen, G. M.; Turner Mj, 3rd (1988 Feb). „Synthesis of spin traps specific for hydroxyl radical”. J Med Chem. 31 (2): 428—32. PMID 2828624. doi:10.1021/jm00397a028. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Rosen, G. M.; Demos, H. A.; Rauckman, E. J. (1984 Aug). „Not all aromatic nitro compounds form free radicals”. Toxicol Lett. 22 (2): 145—52. PMID 6089382. doi:10.1016/0378-4274(84)90058-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. Earley, J. V.; Fryer, R. I.; Ning, R. Y. (1979 Jul). „Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development”. J Pharm Sci. 68 (7): 845—50. Bibcode:1979JPhmS..68..845E. PMID 458601. doi:10.1002/jps.2600680715. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Clonazepam Архивирано на веб-сајту Wayback Machine (6. новембар 2013)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyken P, Sato S: Serum clonazepam concentrations in children with absence seizures. Neurology. Dreifuss, F. E.; Penry, J. K.; Rose, S. W.; Kupferberg, H. J.; Dyken, P.; Sato, S. (1975 Mar). „Serum clonazepam concentrations in children with absence seizures”. Neurology. 25 (3): 255—8. PMID 1089913. doi:10.1212/wnl.25.3.255. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Robertson, M. D.; Drummer, O. H. (1995 May). „Postmortem drug metabolism by bacteria”. J Forensic Sci. 40 (3): 382—6. PMID 7782744. doi:10.1520/JFS13791J. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Rosen GM, Turner MJ 3rd: Synthesis of spin traps specific for hydroxyl radical. Rosen, G. M.; Turner Mj, 3rd (1988 Feb). „Synthesis of spin traps specific for hydroxyl radical”. J Med Chem. 31 (2): 428—32. PMID 2828624. doi:10.1021/jm00397a028. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Rosen, G. M.; Demos, H. A.; Rauckman, E. J. (1984 Aug). „Not all aromatic nitro compounds form free radicals”. Toxicol Lett. 22 (2): 145—52. PMID 6089382. doi:10.1016/0378-4274(84)90058-4. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. Earley, J. V.; Fryer, R. I.; Ning, R. Y. (1979 Jul). „Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development”. J Pharm Sci. 68 (7): 845—50. Bibcode:1979JPhmS..68..845E. PMID 458601. doi:10.1002/jps.2600680715. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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