Pukatein

Pukatein
(IUPAC) ime
	(7aR)-7-metil-6,7,7a,8-tetrahidro-5H-benzo[g][1,3]benzodioksolo[6,5,4-de]hinolin-12-ol
Klinički podaci
Identifikatori
CAS broj	81-67-4
ATC kod	nije dodeljen
PubChem	442340
ChEMBL	CHEMBL258370
Hemijski podaci
Formula	C18H17NO3
Mol. masa	295,332 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H17NO3/c1-19-6-5-11-8-14-18(22-9-21-14)17-15(11)12(19)7-10-3-2-4-13(20)16(10)17/h2-4,8,12,20H,5-7,9H2,1H3/t12-/m1/s1 ; Key: IKMXUUHNYQWZBC-GFCCVEGCSA-N
Sinonimi	(R)-11-hydroxy-1,2-methylenedioxyaporphine
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Pukatein je alkaloid koji je prisutan u kori novozelandskog drveta Laurelia novae-zelandiae ("Pukatea"). Ekstrakt kore se koristi kao tradicionalni maorski biljni lek koji deluje kao analgetik.^[4]^[5] Smatra se da je pukatein aktivna komponenta,^[6] jer je sličan po strukturi i aktivnosti sa alkaloidima poput glaucina i tetrahidropalmatina koji su prisutni u kineskim medicinskim biljkama sa analgetskom primenom. Pukatein ima višestruke mehanizme dejstva, pri čemu su najprominentnija njegova dejstva kao agonist D₂ dopaminskog receptora i antagonist α1 adrenergičkog receptora.^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Pukatea. Te Ara: The Encyclopedia of New Zealand”. Arhivirano iz originala na datum 2008-10-22. Pristupljeno 2014-04-05.
↑ Pukatea. University of Otago Pharmacy Dept.
↑ Fogg WS. The Pharmacological Action of Pukateine. Journal of Pharmacology And Experimental Therapeutics. 1935 Jun;54(2):167-187.
↑ Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F. Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission. General Pharmacology. 1999 Mar;32(3):373-9. PMID 10211594
↑ Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD. Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes. Planta Medica. 2004 Jul;70(7):603-9. PMID 15254852

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] „Pukatea. Te Ara: The Encyclopedia of New Zealand”. Arhivirano iz originala na datum 2008-10-22. Pristupljeno 2014-04-05.

[5] Pukatea. University of Otago Pharmacy Dept.

[6] Fogg WS. The Pharmacological Action of Pukateine. Journal of Pharmacology And Experimental Therapeutics. 1935 Jun;54(2):167-187.

[7] Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F. Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission. General Pharmacology. 1999 Mar;32(3):373-9. PMID 10211594

[8] Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD. Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes. Planta Medica. 2004 Jul;70(7):603-9. PMID 15254852

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