ଆଲପେଲିସିବ

ଆଲପେଲିସିବ
Clinical data
Trade names	Piqray
Synonyms	BYL719
AHFS/Drugs.com	monograph
MedlinePlus	a619036
data	EU EMA: yes; US DailyMed: Alpelisib;
Pregnancy; category	AU: D ; US: N (Not classified yet) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name (2S)-1-N-[4-Methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide;
ECHA InfoCard	100.233.704
Chemical and physical data
Formula	C19H22F3N5O2S
Molar mass	୪୪୧.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F;
	InChI InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1; Key:STUWGJZDJHPWGZ-LBPRGKRZSA-N;

ଆଲପେଲିସିବ, ବିକ୍ରୟ ନାମ ପିକ୍ରାଇ, ହେଉଛି ଏକ କେମୋଥେରାପି ଔଷଧ ଯାହାକି କେତେକ ପ୍ରକାରର ସ୍ତନ କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୫] ଏହା ଫଲଭେଷ୍ଟ୍ରାଣ୍ଟ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ । ^[୫] ରୋଗ ଖରାପ ନହୋଇ ପ୍ରାୟ ୫ ମାସର ଜୀବନ ଅଧିକ ଦେଇଥାଏ । ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା, ବୃକ୍‌କ ସମସ୍ୟା, ତରଳ ଝାଡ଼ା, ରାସ, ନିମ୍ନ ରକ୍ତ କଣିକା, ଯକୃତ ସମସ୍ୟା, ଅଗ୍ନାଶୟ ପ୍ରଦାହ, ବାନ୍ତି ଏବଂ କେଶହାନୀ ହୋଇପାରେ । ^[୬] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲାକ୍ସିସ୍, ଅନୁର୍ବରତା ଏବଂ ନିମୋନିଆ ହୋଇପାରେ । ^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୫] ଏହା ଏକ ଆଲଫା-ନିର୍ଦ୍ଦିଷ୍ଟ ପିଆଇକେ (PI3K) ପ୍ରତିବନ୍ଧକ । ^[୫]

୨୦୧୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୦ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୪]^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ଔଷଧର ଏକ ମାସ ଖର୍ଚ୍ଚର ମୂଲ୍ୟ ୧୭,୦୦୦ ଡଲାର । ^[୭]

ଆଧାର

1 2 "Piqray Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 27 March 2020. Archived from the original on 27 August 2021. Retrieved 16 August 2020.
↑ "Alpelisib (Piqray) Use During Pregnancy". Drugs.com. 29 July 2019. Archived from the original on 3 December 2020. Retrieved 16 August 2020.
↑ "Piqray- alpelisib tablet Piqray- alpelisib kit". DailyMed. 12 June 2020. Archived from the original on 28 October 2020. Retrieved 16 August 2020.
1 2 3 "Piqray EPAR". European Medicines Agency (EMA). 26 May 2020. Archived from the original on 14 August 2020. Retrieved 16 August 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1 2 3 4 5 6 7 "Alpelisib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 November 2019. Retrieved 19 July 2021.
↑ "FDA approves first PI3K inhibitor for breast cancer" (Press release). 24 May 2019. Archived from the original on 25 November 2019. Retrieved 29 May 2019.
↑ "Piqray Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 October 2021. Retrieved 19 July 2021.

[Piqray_APMDS-1] 1 2 "Piqray Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 27 March 2020. Archived from the original on 27 August 2021. Retrieved 16 August 2020.

[Drugs.com_pregnancy-2] "Alpelisib (Piqray) Use During Pregnancy". Drugs.com. 29 July 2019. Archived from the original on 3 December 2020. Retrieved 16 August 2020.

[Piqray_FDA_label-3] "Piqray- alpelisib tablet Piqray- alpelisib kit". DailyMed. 12 June 2020. Archived from the original on 28 October 2020. Retrieved 16 August 2020.

[EMA2020-4] 1 2 3 "Piqray EPAR". European Medicines Agency (EMA). 26 May 2020. Archived from the original on 14 August 2020. Retrieved 16 August 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[AHFS2021-5] 1 2 3 4 5 6 7 "Alpelisib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 November 2019. Retrieved 19 July 2021.

[FDA2019-6] "FDA approves first PI3K inhibitor for breast cancer" (Press release). 24 May 2019. Archived from the original on 25 November 2019. Retrieved 29 May 2019.

[7] "Piqray Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 October 2021. Retrieved 19 July 2021.

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