rpoE
| ECF RNA polymerase sigma-E factor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | rpoE | ||||||
| Alt. symbols | sigE | ||||||
| Entrez | 67175910 | ||||||
| Orthologs | NCBI: entry; OMA: entry | ||||||
| PDB | 1OR7, 2H27, 5OR5, 6JBQ | ||||||
| RefSeq (mRNA) | NC_000913 | ||||||
| RefSeq (Prot) | NP_417068 | ||||||
| UniProt | P0AGB6 | ||||||
| Other data | |||||||
| Chromosome | genomic: 2.71 - 2.71 Mb | ||||||
| |||||||
The gene rpoE (RNA polymerase, extracytoplasmic E) encodes the sigma factor sigma-24 (σ24, sigma E, or RpoE), a protein in Escherichia coli[1] and other species of bacteria. Depending on the bacterial species, this gene may be referred to as sigE.[2]
RpoE appears to be necessary for the exocytoplasmic stress response. E. coli mutants without rpoE cannot grow at high temperatures (that is, above 42 degrees C)[3] and show growth defects at lower temperatures, though this may be due to compensatory mutations.[4]
The stress response regulation activities of RpoE are modulated by the Hfq protein in E. coli.[4]
References
[edit]- ↑ Rouvière PE, De Las Peñas A, Mecsas J, Lu CZ, Rudd KE, Gross CA (March 1995). "rpoE, the gene encoding the second heat-shock sigma factor, sigma E, in Escherichia coli". The EMBO Journal. 14 (5): 1032–1042. doi:10.1002/j.1460-2075.1995.tb07084.x. PMC 398175. PMID 7889934.
- ↑ Jensen-Cain DM, Quinn FD (May 2001). "Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth". Microbial Pathogenesis. 30 (5): 271–278. doi:10.1006/mpat.2001.0431. PMID 11373121.
- ↑ Hiratsu K, Amemura M, Nashimoto H, Shinagawa H, Makino K (May 1995). "The rpoE gene of Escherichia coli, which encodes sigma E, is essential for bacterial growth at high temperature". Journal of Bacteriology. 177 (10): 2918–2922. doi:10.1128/jb.177.10.2918-2922.1995. PMC 176969. PMID 7751307.
- 1 2 De Las Peñas A, Connolly L, Gross CA (November 1997). "SigmaE is an essential sigma factor in Escherichia coli". Journal of Bacteriology. 179 (21): 6862–6864. doi:10.1128/jb.179.21.6862-6864.1997. PMC 179621. PMID 9352942.
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