3-Epi-6-deoxocathasterone 23-monooxygenase (EC 1.14.14.147, cytochrome P450 90C1, CYP90D1, CYP90C1) is an enzyme with systematic name 3-epi-6-deoxocathasterone,NADPH:oxygen oxidoreductase (C-23-hydroxylating).[1] This enzyme catalyses the following chemical reaction
| 3-Epi-6-deoxocathasterone 23-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.147 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme can insert a hydroxy group into other similar compounds, for example to give 3-dehydro-6-deoxoteasterone. It is a cytochrome P450 protein containing heme, isolated from Arabidopsis thaliana, and requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate.[2] 3-Epi-6-deoxocathasterone 23-monooxygenase takes part in brassinosteroid biosynthesis.[3]
References
edit- ↑ Ohnishi T, Szatmari AM, Watanabe B, Fujita S, Bancos S, Koncz C, Lafos M, Shibata K, Yokota T, Sakata K, Szekeres M, Mizutani M (November 2006). "C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis". The Plant Cell. 18 (11): 3275–88. Bibcode:2006PlanC..18.3275O. doi:10.1105/tpc.106.045443. PMC 1693957. PMID 17138693.
- ↑ Enzyme 1.14.14.147 at KEGG Pathway Database.
- ↑ Kim, Gyung-Tae; Fujioka, Shozo; Kozuka, Toshiaki; Tax, Frans E.; Takatsuto, Suguru; Yoshida, Shigeo; Tsukaya, Hirokazu (2005). "CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana". The Plant Journal. 41 (5): 710–721. doi:10.1111/j.1365-313X.2004.02330.x. PMID 15703058.
External links
edit- 3-epi-6-deoxocathasterone+23-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
