1P-ETH-LAD

1P-ETH-LAD
Clinical data
Other names	1-Propionyl-ETH-LAD; 1-Propionyl-6-ethyl-6-nor-LSD
Routes of; administration	Oral
Drug class	Serotonergic psychedelic; Hallucinogen
Legal status
Legal status	DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act; Illegal in France;
Identifiers
	IUPAC name (6aR,9R)-N,N-Diethyl-7-ethyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide;
CAS Number	2230715-45-2 ;
PubChem CID	119025859;
ChemSpider	52085137 ;
UNII	HA76076A0R;
CompTox Dashboard (EPA)	DTXSID301016300 ;
Chemical and physical data
Formula	C24H31N3O2
Molar mass	393.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)N1C=C2C[C@@H]3C(=C[C@H](CN3CC)C(=O)N(CC)CC)C4=C2C1=CC=C4;
	InChI InChI=1S/C24H31N3O2/c1-5-22(28)27-15-16-13-21-19(18-10-9-11-20(27)23(16)18)12-17(14-26(21)8-4)24(29)25(6-2)7-3/h9-12,15,17,21H,5-8,13-14H2,1-4H3/t17-,21-/m1/s1 ; Key:MLOFCBXSOAYCIF-DYESRHJHSA-N ;

1P-ETH-LAD, also known as 1-propionyl-6-ethyl-6-nor-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).^[2] It is the 1-propionyl derivative of ETH-LAD and is thought to act as a prodrug of ETH-LAD analogously to how 1P-LSD acts as a prodrug of LSD.^[2]

Use and effects

Like ETH-LAD, this drug has been reported to be significantly more potent than LSD itself, and is reported to largely mimic ETH-LAD's psychedelic effects.^{[citation needed]}

Interactions

Pharmacology

Research has shown formation of ETH-LAD from 1P-ETH-LAD incubated in human serum, suggesting that it functions as a prodrug.^[2]

Chemistry

Analogues

Analogues of 1P-ETH-LAD include 1P-LSD and 1P-AL-LAD, among others.

History

1P-ETH-LAD has little history of human usage before January 2016.^{[citation needed]}

Society and culture

Legal status

Canada

1P-ETH-LAD is not a controlled substance in Canada as of 2025.^[3]

United Kingdom

It is illegal to produce, supply, or import 1P-ETH-LAD under the Psychoactive Substance Act, which came into effect on May 26, 2016.^[4]

United States

1P-ETH-LAD is not an explicitly controlled substance in the United States.^[5] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

References

↑ "Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants". www.legifrance.gouv.fr (in French). 20 May 2021.
1 2 3 Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, et al. (October 2017). "6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD)". Drug Testing and Analysis. 9 (10): 1641–1649. doi:10.1002/dta.2196. PMC 6230477. PMID 28342178.
↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
↑ "Psychoactive Substances Act 2016". Legislation.gov.uk.
↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026

External links

[1] "Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants". www.legifrance.gouv.fr (in French). 20 May 2021.

[BrandtKavanaghWestphal2017-2] 1 2 3 Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, et al. (October 2017). "6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD)". Drug Testing and Analysis. 9 (10): 1641–1649. doi:10.1002/dta.2196. PMC 6230477. PMID 28342178.

[CDSA-3] "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.

[4] "Psychoactive Substances Act 2016". Legislation.gov.uk.

[OrangeBook2026-5] Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026

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