1-Pyrroline-5-carboxylate dehydrogenase
| 1-pyrroline-5-carboxylate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.88 | ||||||||
| CAS no. | 9054-82-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction
-1-pyrroline-5-carboxylic_acid.svg)
The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, nicotinamide adenine dinucleotide (NAD+), and water. The starting material is in chemical equilibrium with L-glutamate-5-semialdehyde, which is oxidised to L-glutamic acid, giving reduced NADH, and a proton.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.
Structural studies
[edit]As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2BHP, PDB: 2BHQ, PDB: 2BJA, PDB: 2BJK, PDB: 2EHQ, PDB: 2EHU, PDB: 2EII, PDB: 2EIT, PDB: 2EIW, PDB: 2EJ6, PDB: 2EJD, PDB: 2EJL, PDB: 2IY6, and PDB: 2J40.
Human gene
[edit]In human, the protein is encoded by ALDH4A1 gene.
References
[edit]- ↑ Enzyme 1.2.1.88 at KEGG Pathway Database.
- ↑ Adams E, Goldstone A (December 1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate". The Journal of Biological Chemistry. 235 (12): 3504–12. doi:10.1016/S0021-9258(18)64498-9. PMID 13681370.
- ↑ Strecker HJ (1960). "The interconversion of glutamic acid proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223. doi:10.1016/S0021-9258(20)81340-4.
