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Review

Fluoxetine

No authors listed
In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
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Review

Fluoxetine

No authors listed.
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Excerpt

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) widely used as an antidepressant. Fluoxetine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.

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References

    1. Zimmerman HJ. Antidepressants. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 493-8.(Expert review of hepatotoxicity published in 1999; mentions that there have been at least 6 reports of acute, symptomatic hepatic injury and one case of chronic hepatitis attributed to fluoxetine).
    1. Larrey D, Ripault MP. Hepatotoxicity of psychotropic drugs and drugs of abuse. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 443-62.(Review of hepatotoxicity of antidepressants; clinically apparent liver injury from the SSRIs is rare, and fluoxetine has been implicated in only a few isolated cases).
    1. O'Donnell JM, Shelton RC. Pharmacotherapy of depression and anxiety disorders. In, Brunton LL, Chabner BA, Knollman BC, eds. Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill, 2011, pp. 397-416.(Textbook of pharmacology and therapeutics).
    1. Cooper GL. The safety of fluoxetine – an update. Br J Psychiatry 1988; 153: 77-86. (Pooled data on 2938 patients on fluoxetine, 599 on tricyclics and 799 on placebo and postmarketing data on over 7500 fluoxetine treated patients; AST values above 100 U/L occurred in 0.5% of patients on fluoxetine, but there were no cases of clinically apparent liver injury). - PubMed
    1. Lam KS, Blanchi A, Chavaillon JM. [Hepatitis probably secondary to the massive ingestion of fluvoxamine]. Gastroenterol Clin Biol 1988; 12: 398-9. (63 year old woman took an overdose of fluvoxamine [~1500 mg] and within 24 hours had elevations in ALT [1059 U/L], Alk P [668 U/L] and bilirubin [1.4 mg/dL], which remained high for more than a month). - PubMed

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