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Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens

EasyFuse detects gene fusions in cancer transcriptomes for personalized immunotherapy.

David Weber
Jonas Ibn-Salem
Ugur Sahin
Research04 Apr 2022
Nature Biotechnology

Volume: 40, P: 1276-1284
An apoplastic peptide activates salicylic acid signalling in maize

In maize, a small apoplastic peptide named Zip1 is the missing link between papain-like cysteine proteases and salicylic acid (SA) signalling. Zip1 can trigger defence responses similar to SA and affect immunity towards pathogenic fungi.

Sebastian Ziemann
Karina van der Linde
Gunther Doehlemann
Research26 Feb 2018
Nature Plants

Volume: 4, P: 172-180
Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

Francis Martin and colleagues report genome sequences for 18 species of mycorrhizal fungi and a phylogenomic analysis including 32 other fungal genomes. The study identifies cell wall-degradation genes lost in all true ectomycorrhizal species and, using gene expression data, finds candidate genes for the establishment of symbiosis.

Annegret Kohler
Alan Kuo
Francis Martin
ResearchOpen Access23 Feb 2015
Nature Genetics

Volume: 47, P: 410-415

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