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Information on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.2.1.3

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IUBMB Comments

Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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an aldehyde
+
NAD+
+
H2O
=
a carboxylate
+
NADH
+
H+
+
+
=
+
+

Synonyms
aldh2, aldh1, aldh1a1, aldehyde dehydrogenase 2, aldh1a3, aldh3a1, aldehyde dehydrogenase 1, aldh1a2, mitochondrial aldehyde dehydrogenase, aldehyde dehydrogenase-2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
3-methyl-branched fatty acid alpha-oxidation, alkane oxidation, aromatic biogenic amine degradation (bacteria), ceramide and sphingolipid recycling and degradation (yeast), ceramide degradation by alpha-oxidation, dopamine degradation, ethanol degradation II, ethanol degradation III, ethanol degradation IV, fatty acid alpha-oxidation I (plants), histamine degradation, hypotaurine degradation, L-tryptophan degradation X (mammalian, via tryptamine), limonene degradation IV (anaerobic), mitochondrial NADPH production (yeast), noradrenaline and adrenaline degradation, octane oxidation, phytol degradation, putrescine degradation III, serotonin degradation, sphingosine and sphingosine-1-phosphate metabolism
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