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Vaccine Innovation: Lessons from World War II

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Abstract

World War II marked a watershed in the history of vaccine development as the military, in collaboration with academia and industry, achieved unprecedented levels of innovation in response to war-enhanced disease threats such as influenza and pneumococcal pneumonia. In the 1940s alone, wartime programs contributed to the development of new or significantly improved vaccines for 10 of the 28 vaccine-preventable diseases identified in the 20th century. This article examines the historical significance of military organizations and national security concerns for vaccine development in the United States.

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References

  • Baxter JP . Scientists Against Time. Cambridge: MIT Press; 1947.

    Google Scholar 

  • von Hippel E . The Sources of Innovation. Oxford: Oxford University Press; 1988.

    Google Scholar 

  • The Surgeon General's Report to the Secretary of War for the Fiscal Year of 1940. National Archives: RG 112, E. 1014, B. 1.

  • Crosby A . Epidemics and Peace, 1918. Westport, CT: Greenwood Press; 1976.

    Google Scholar 

  • Johnson NP, Mueller J . Updating the accounts: Global mortality of the 1918–1920 “Spanish” influenza pandemic. Bull Hist Med. 2002;76:105–115.

    Article  Google Scholar 

  • Francis Jr T . Influenza in the US Army Medical Service. Preventive Medicine in World War II, vol. IV. Washington DC: US Government Printing Office; 1958, pp. 85–87.

    Google Scholar 

  • Department of Defense. Addressing Emerging Infectious Disease Threats: A Strategic Plan for the Department of Defense. Washington DC: Walter Reed Army Institute of Research; 1998, p. 23.

  • Francis Jr T . Influenza in the US Army Medical Service. Preventive Medicine in World War II, vol. IV. Washington DC: US Government Printing Office; 1958, pp. 85–87.

    Google Scholar 

  • Woodward T . The Armed Forces Epidemiological Board: Its First 50 Years. Falls Church, VA: Center of Excellence in Military Medical Research and Education, Office of the Surgeon General, Department of the Army; 1990.

    Google Scholar 

  • History of the Relation of the SGO to BW Activities. National Archives: RG: 112, E. 295A, B. 13.

  • Digest of Information Regarding Axis Activities in the Field of Bacteriological Warfare. Washington DC: National Academy of Sciences, Committee on Biological Warfare Files; 1943.

  • Dammin G, Robinson E . Medical Laboratories. In: Col. Robert Anderson, editor. Preventive medicine in World War II, vol. IX. Washington DC: Special Fields, Medical Department of the U.S. Army; 1969, p. 578.

    Google Scholar 

  • Richards AN, Quoted in: Andrus EC et al., editors. Advances in Military Medicine, vol. I. Boston: Little, Brown and Company; 1948.

    Google Scholar 

  • Brig. General Bayne-Jones S Director of the USA. Typhus Commission. National Archives: RG 156, E. 488, B. 183.

  • Bush V . Comments on the Subject of Organization for Research. Letter to Karl Compton. Library of Congress: Vannevar Bush Papers, Container 138; October 24, 1946.

    Google Scholar 

  • Francis T, Tillet W . Cutaneous reactions in pneumonia: the development of antibodies following the intradermal injection of type-specific polysaccharides. J Exp Med. 1938;52:573.

    Article  Google Scholar 

  • Felton L . Studies on immunizing substances in pneumococci: response in human beings to antigenic pneumococcus polysaccharides Type I and II. Public Health Rep. 1930;53:1833.

    Google Scholar 

  • Ekwurzel G, et al. Studies on immunizing substances in pneumococci: report on field Tests to determine the prophylactic value of a pneumococcus antigen. Public Health Rep. 1938;53:1877.

    Article  Google Scholar 

  • MacLeod CM, et al. Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides. J Exp Med. 1945;82(6):445.

    Article  Google Scholar 

  • Heidelberger M . A “Pure” organic chemist's downward path. Ann Rev Biochem. 1979;48:1–21.

    Article  Google Scholar 

  • Stanley WM . The preparation of and properties of influenza virus vaccinees concentrated and purified by differential centrifugation. J Exp Med. 1945;18:193–218.

    Article  Google Scholar 

  • Taylor AR, Sharp DG, McLean Jr IW, Beard D, Beard JW . Concentration and purification of influenza virus for the preparation of vaccines. J Immunol. 1944;50:291–316.

    Google Scholar 

  • Francis T . Influenza. In: Col. John Boyd Coates, Jr MC, editor. Communicable Diseases Transmitted Chiefly Through Respiratory and Alimentary Tracts, vol. IV: Preventive Medicine. Washington DC: US Government Printing Office; 1958, p. 121.

    Google Scholar 

  • Members of the Commission on Influenza and Other Epidemic Diseases in the Army. A clinical evaluation of vaccination against influenza. J Am Med Assoc. 1944;124:982–985.

  • The Research Program of the War Research Service. WRS report for the ABC Sub-Committee. Washington DC: National Academy of Sciences, Committee on Biological Warfare Files; May 13, 1944.

  • James Conant . Letter to the editor. The New York Times, August 3, 1945 (in response to an unfavorable editorial regarding Bush's proposals in Science: The Endless Frontier. National Archives: RG 227, E. 2, B. 1.

  • von Hippel E, Thomke W, Sonnack M . Creating breakthroughs at 3M. Harvard Bus Rev. September/October, 1999;77(5).

  • Hays SB . Preventive Medicine in World War II, vol. IV. In: John Boyd Coates Jr. MC editor. Washington DC: US Government Printing Office; 1958.

    Google Scholar 

  • Chase A . Magic Shots. New York: William Morrow and Company; 1982, p. 197.

    Google Scholar 

  • Crosby A . Ecological Imperialism; The Biological Expansion of Europe, 900–1900. Cambridge: Cambridge University Press; 1986.

    Google Scholar 

  • Gordon J . General considerations of modes of transmission. In: Col. John Boyd Coates Jr MC, editors. Communicable Diseases Transmitted Chiefly Through Respiratory and Alimentary Tracts: Preventive Medicine in World War II, vol. IV. Washington DC: US Government Printing Office; 1958, p. 5.

    Google Scholar 

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Correspondence to Kendall Hoyt.

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An examination of the US Army's approach to vaccine development during World War II reveals unprecedented innovation and a close and effective relationship between researchers and end users.

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Hoyt, K. Vaccine Innovation: Lessons from World War II. J Public Health Pol 27, 38–57 (2006). https://doi.org/10.1057/palgrave.jphp.3200064

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