AmiGO 2: Term Details for "bone remodeling" (GO:0046849)

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Term Information

Accession: GO:0046849
Name: bone remodeling
Ontology: biological_process
Synonyms: bone remodelling
Alternate IDs: None
Definition: The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. Source: GOC:curators
Comment: None
History: See term history for GO:0046849 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to bone remodeling (excluding "regulates").; Link to all direct and indirect annotations to bone remodeling (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for bone remodeling (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0032501 multicellular organismal process
GO:0048771 tissue remodeling
GO:0046849 bone remodeling
GO:0045453 bone resorption
GO:0046851 negative regulation of bone remodeling
GO:0043932 ossification involved in bone remodeling
GO:0046852 positive regulation of bone remodeling
GO:0046850 regulation of bone remodeling

Parents of bone remodeling (GO:0046849)

subject	relation	object
bone remodeling	is_a	tissue remodeling (GO:0048771)

Children of bone remodeling (GO:0046849)

subject	relation	object
positive regulation of bone remodeling (GO:0046852)	RO:0002213	bone remodeling
negative regulation of bone remodeling (GO:0046851)	RO:0002212	bone remodeling
ossification involved in bone remodeling (GO:0043932)	BFO:0000050	bone remodeling
regulation of bone remodeling (GO:0046850)	RO:0002211	bone remodeling
bone resorption (GO:0045453)	BFO:0000050	bone remodeling

Wikipedia: Bone_remodeling